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var(--color-brand);border-radius:var(--radius-md);background:var(--color-brand);color:var(--color-brand-fg);font-size:var(--text-sm);cursor:pointer;transition:background var(--transition-fast), border-color var(--transition-fast);min-height:44px;font-weight:500;font-family:var(--font-sans);padding:.55rem 1rem;display:inline-flex}.empty-state__file-label:hover{background:var(--color-brand-hover);border-color:var(--color-brand-hover)}.dropzone:has(#file-input:focus-visible) #empty-state:not(.hidden) .empty-state__file-label{outline:3px solid var(--color-focus-ring);outline-offset:2px;border-radius:var(--radius-md)}.empty-state__sample-btn{align-items:center;gap:var(--space-2);border:1px solid var(--color-border-strong);border-radius:var(--radius-md);background:var(--color-surface);color:var(--color-text);font-size:var(--text-sm);cursor:pointer;transition:background var(--transition-fast), border-color var(--transition-fast);min-height:44px;font-weight:500;font-family:var(--font-sans);padding:.55rem 1rem;display:inline-flex}.empty-state__sample-btn:hover{background:var(--color-surface-raised);border-color:var(--color-brand);color:var(--color-brand)}.empty-state__hint{font-size:var(--text-xs);color:var(--color-text-muted);margin:0}.status-banner{align-items:center;gap:var(--space-3);padding:var(--space-3) var(--space-4);border-radius:var(--radius-md);font-size:var(--text-sm);margin-top:var(--space-3);display:flex}.status-banner--loading{background:var(--color-surface-raised);border:1px solid var(--color-border);color:var(--color-text-muted)}.status-banner--error{background:var(--color-error-bg);border:1px solid var(--color-error-border);color:var(--color-error-text)}.status-banner--success{background:var(--color-success-bg);border:1px solid var(--color-success-border);color:var(--color-success-text)}.status-banner--sample{margin-top:0;margin-bottom:var(--space-3);background:var(--color-surface-raised);border:1px solid var(--color-border);color:var(--color-text);justify-content:space-between}.status-banner__dismiss{border:1px solid var(--color-border-strong);border-radius:var(--radius-sm);background:var(--color-surface);color:inherit;font:inherit;cursor:pointer;padding:.35rem .65rem}.status-banner__dismiss:hover{background:var(--color-surface-raised)}@keyframes spin{to{transform:rotate(360deg)}}.spinner{border-radius:var(--radius-full);border:2px solid;border-top-color:#0000;flex-shrink:0;width:1em;height:1em;animation:.7s linear infinite spin;display:inline-block}@media 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solid var(--color-focus-ring);outline-offset:1px}.annotation-chip--orf{background:var(--color-annotation-chip-orf-bg);border-color:var(--color-annotation-chip-orf-border)}.annotation-chip--restriction{background:var(--color-annotation-chip-restriction-bg);border-color:var(--color-annotation-chip-restriction-border)}.plasmid-map{border:1px solid var(--color-plasmid-border);border-radius:var(--radius-md);background:var(--color-plasmid-bg);padding:var(--space-2);margin-top:.75rem}.plasmid-map__header{justify-content:space-between;align-items:center;gap:var(--space-2);display:flex}.plasmid-map__title{font-size:var(--text-sm);color:var(--color-text);margin:0}.plasmid-map__controls{gap:var(--space-1);display:inline-flex}.plasmid-map__toggle{border:1px solid var(--color-border);border-radius:var(--radius-sm);background:var(--color-surface);color:var(--color-text);font-size:var(--text-xs);cursor:pointer;padding:.2rem .5rem}.plasmid-map__toggle[aria-pressed=true]{border-color:var(--color-brand);background:var(--color-accent-bg)}.plasmid-map__toggle:focus-visible,.plasmid-map__marker:focus-visible{outline:3px solid var(--color-focus-ring);outline-offset:1px}.plasmid-map__body{margin-top:var(--space-2)}.plasmid-map__circular{aspect-ratio:1;width:min(320px,100%);margin:0 auto;position:relative}.plasmid-map__circle-backbone{border:4px solid var(--color-plasmid-backbone);border-radius:var(--radius-full);position:absolute;inset:16%}.plasmid-map__circle-markers{position:absolute;inset:0}.plasmid-map__linear{min-height:64px;position:relative}.plasmid-map__linear-backbone{border-top:3px solid 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(orientation:portrait){.canvas-wrap{height:min(42vh, var(--canvas-portrait-max-height))}}.metadata-panel{background:var(--color-surface);border:1px solid var(--color-border);border-radius:var(--radius-md);font-size:var(--text-sm);margin-top:.75rem;padding:.75rem}.metadata-header{color:var(--color-text-muted);font-weight:600;font-size:var(--text-xs);text-transform:uppercase;letter-spacing:.06em;margin-bottom:.5rem}.metadata-rows{grid-template-columns:max-content 1fr;gap:.2rem 1rem;display:grid}.metadata-row{display:contents}.metadata-label{color:var(--color-text-muted);white-space:nowrap}.metadata-value{color:var(--color-text);word-break:break-word;font-family:var(--font-mono)}.workspace-bar{background:var(--color-surface);border:1px solid var(--color-border);border-radius:var(--radius-md);scrollbar-width:thin;align-items:center;gap:.25rem;margin-bottom:.5rem;padding:.25rem 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.contig-panel__status-text{color:var(--color-success-text)}.contig-panel__body{margin-top:var(--space-3)}.contig-panel__summary{color:var(--color-contig-summary-fg);margin-bottom:var(--space-3);font-weight:600;font-size:var(--text-sm)}.contig-panel__rows{gap:var(--space-1);flex-direction:column;display:flex;overflow-x:auto}.contig-panel__row{align-items:center;gap:var(--space-2);min-height:2rem;display:flex}.contig-panel__row-label{font-family:var(--font-mono);font-size:var(--text-xs);color:var(--color-text-muted);text-align:right;flex-shrink:0;min-width:3rem;font-weight:700}.contig-panel__seq{font-family:var(--font-mono);font-size:var(--text-sm);letter-spacing:.05em;padding:var(--space-1) var(--space-2);border-radius:var(--radius-sm);border:1px solid #0000;flex-wrap:nowrap;display:flex;overflow-x:visible}.contig-panel__row:first-child .contig-panel__seq{background:var(--color-contig-fwd-bg);border-color:var(--color-contig-fwd-border)}.contig-panel__row:nth-child(2) .contig-panel__seq{background:var(--color-contig-rev-bg);border-color:var(--color-contig-rev-border)}.contig-panel__row--cons .contig-panel__seq{background:var(--color-contig-cons-bg);border-color:var(--color-contig-cons-border);font-weight:600}.contig-base{min-width:1ch;display:inline-block}.contig-base--gap{color:var(--color-contig-gap-fg)}.contig-base--overlap{background:var(--color-contig-overlap-bg)}.contig-base--mismatch{background:var(--color-contig-mismatch-bg);color:var(--color-contig-mismatch-fg);border-bottom:2px solid var(--color-contig-mismatch-border);border-radius:2px;font-weight:700}#print-view{display:none}@media print{body>:not(#print-view){display:none!important}#print-view{color:#000;background:#fff;font-family:Georgia,Times New Roman,serif;font-size:11pt;display:block}@page{size:A4 landscape;margin:1.5cm 1.8cm}.print-header{page-break-inside:avoid;border-bottom:2pt solid #000;margin-bottom:12pt;padding-bottom:6pt}.print-header__title{margin:0 0 6pt;font-size:16pt;font-weight:700}.print-header__meta{grid-template-columns:max-content 1fr;gap:2pt 12pt;margin:0;font-size:9pt;display:grid}.print-header__term{color:#444;margin:0;font-weight:700}.print-header__def{margin:0;font-family:Courier New,Courier,monospace}.print-section__heading{text-transform:uppercase;letter-spacing:.05em;color:#444;border-bottom:.5pt solid #ccc;margin:10pt 0 4pt;padding-bottom:2pt;font-size:10pt;font-weight:700}.print-chromatogram,.print-quality{page-break-inside:avoid;margin-bottom:6pt}.print-chromatogram__img,.print-quality__img{width:100%;max-width:100%;height:auto;display:block}.print-sequence{page-break-inside:avoid;margin-bottom:6pt}.print-sequence__bases{white-space:pre-wrap;word-break:break-all;margin:0;font-family:Courier New,Courier,monospace;font-size:8.5pt;line-height:1.4}.print-annotations{page-break-inside:avoid;color:#333;margin-bottom:6pt;font-size:9pt}}.reference-panel{background:var(--color-reference-bg);border:1px solid 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var(--space-4);background:var(--color-brand);color:var(--color-brand-fg);border-radius:var(--radius-sm);font-size:var(--text-sm);cursor:pointer;transition:background var(--transition-fast);border:none;font-weight:600}.reference-panel__align-btn:hover:not(:disabled){background:var(--color-brand-hover)}.reference-panel__align-btn:focus-visible{outline:3px solid var(--color-focus-ring);outline-offset:2px}.reference-panel__align-btn:disabled{opacity:.45;cursor:not-allowed}.reference-panel__clear-btn{padding:var(--space-1) var(--space-3);color:var(--color-text-muted);border:1px solid var(--color-border);border-radius:var(--radius-sm);font-size:var(--text-sm);cursor:pointer;transition:color var(--transition-fast), border-color var(--transition-fast);background:0 0}.reference-panel__clear-btn:hover{color:var(--color-text);border-color:var(--color-border-strong)}.reference-panel__clear-btn:focus-visible{outline:3px solid var(--color-focus-ring);outline-offset:2px}.reference-panel__status{margin-top:var(--space-2);min-height:1.4em}.reference-panel__status-text{font-size:var(--text-xs);color:var(--color-text-muted)}.reference-panel[data-status-kind=success] .reference-panel__status-text{color:var(--color-success-text)}.reference-panel[data-status-kind=error] .reference-panel__status-text{color:var(--color-error-text)}.variant-table{margin:var(--space-4) 0;border:1px solid var(--color-border);border-radius:var(--radius-md);overflow:hidden}.variant-table__header{align-items:center;gap:var(--space-3);padding:var(--space-3) var(--space-4);background:var(--color-surface-raised);border-bottom:1px solid var(--color-border);flex-wrap:wrap;display:flex}.variant-table__title{font-size:var(--text-sm);flex-shrink:0;margin:0;font-weight:600}.variant-table__tabs{gap:var(--space-1);flex:1;display:flex}.variant-tab{padding:2px var(--space-2);border:1px solid 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.25rem}.sidebar-tab:hover{color:var(--color-text);background:var(--color-hover);border-bottom-color:var(--color-border-strong)}.sidebar-tab[aria-selected=true]{color:var(--color-brand);border-bottom-color:var(--color-brand);background:var(--color-surface);font-weight:600}.sidebar-tab:focus-visible{outline:3px solid var(--color-focus-ring);outline-offset:-2px}.sidebar-panel{padding:var(--space-3);gap:var(--space-2);flex-direction:column;display:flex}.sidebar-panel[hidden]{display:none!important}.sidebar-panel .controls-group{flex-direction:column;align-items:stretch;width:100%}.sidebar-panel .controls-group__label{margin-bottom:var(--space-1)}.sidebar-panel .search-controls,.sidebar-panel .trim-controls,.sidebar-panel .mixed-controls{margin-top:0}@media (width<=900px){.app-shell{flex-direction:column}.shell-sidebar{flex:none;width:100%;min-width:0;max-height:none;position:static}.shell-sidebar[data-sidebar-open=false]{width:100%}.sidebar-inner{max-height:60vh;overflow-y:auto}.sidebar-toggle-btn{text-align:center;width:100%;margin-bottom:var(--space-1);align-self:stretch}}html{scroll-behavior:smooth;min-width:320px}body{background:radial-gradient(circle at 8% 0%, #007b6717, transparent 26rem), radial-gradient(circle at 92% 8%, #d64c2f12, transparent 24rem), var(--color-bg);min-height:100vh}button,input,textarea,select{font:inherit}::selection{background:var(--color-brand);color:var(--color-brand-fg)}.site-header{z-index:20;border-bottom:1px solid #ffffff1c;position:relative;overflow:hidden}.site-header:after{content:"";background:linear-gradient(90deg,#0000,#78dfc3bf,#0000);height:1px;position:absolute;inset:auto 0 0}.site-shell{max-width:1540px}.site-header .site-shell{min-height:64px;padding:.65rem clamp(1rem,3vw,2.25rem)}.site-title{align-items:center;gap:.7rem;min-height:44px;display:inline-flex}.site-title__mark{fill:none;stroke:#89dec8;stroke-width:1.6px;stroke-linecap:round;flex:none;width:32px;height:32px}.site-title__copy{gap:0;display:grid}.site-title__wordmark{font-size:var(--text-base);letter-spacing:-.02em;font-weight:700}.site-title__descriptor{color:#b9d0ca;letter-spacing:.11em;text-transform:uppercase;font-size:.64rem;font-weight:600}.site-nav{align-items:center;gap:.85rem}.site-nav__privacy{color:#c5d9d4;font-size:var(--text-xs);align-items:center;gap:.45rem;font-weight:600;display:inline-flex}.site-nav__privacy>span{border-radius:var(--radius-full);background:#62d7b6;width:7px;height:7px;box-shadow:0 0 0 4px #62d7b621}.site-nav a{border-radius:var(--radius-full);color:#f5fbf9;min-height:40px;font-size:var(--text-sm);border:1px solid #ffffff2e;align-items:center;padding:0 .8rem;font-weight:650;display:inline-flex}.site-nav a:hover{background:#ffffff14;border-color:#ffffff6b}#app{max-width:1540px;padding:clamp(1rem,2.2vw,2rem) clamp(.75rem,3vw,2.25rem) 4rem}.viewer{position:relative}.viewer-intro{grid-template-columns:minmax(0,1fr) auto;align-items:end;gap:clamp(1.5rem,5vw,5rem);margin-bottom:clamp(1rem,2.2vw,1.7rem);padding:clamp(.4rem,1.2vw,1rem) 0;display:grid}.viewer-intro__copy{max-width:820px}.viewer-intro__eyebrow,.empty-state__kicker,.trace-stage__kicker{color:var(--color-brand);letter-spacing:.14em;text-transform:uppercase;align-items:center;gap:.55rem;margin:0 0 .55rem;font-size:.68rem;font-weight:800;display:flex}.viewer-intro__pulse{background:var(--color-warm);width:20px;height:2px;box-shadow:7px -4px 0 -.5px var(--color-warm), 12px 4px 0 -.5px var(--color-warm)}.viewer h1{color:var(--color-text);font-family:var(--font-display);letter-spacing:-.055em;margin:0;font-size:clamp(2.15rem,4.4vw,4.25rem);font-weight:600;line-height:.94}.viewer h1 span{color:var(--color-brand);font-style:italic;font-weight:500}.viewer-intro__summary{max-width:700px;color:var(--color-text-muted);margin:.8rem 0 0;font-size:clamp(.88rem,1.4vw,1.05rem);line-height:1.55}.viewer-intro__proof{border:1px solid var(--color-border);border-radius:var(--radius-lg);background:color-mix(in srgb, var(--color-surface) 88%, transparent);box-shadow:var(--shadow-sm);grid-template-columns:repeat(3,minmax(90px,auto));align-self:center;display:grid;overflow:hidden}.viewer-intro__proof>div{gap:.15rem;min-width:108px;padding:.85rem 1rem;display:grid}.viewer-intro__proof>div+div{border-left:1px solid var(--color-border)}.viewer-intro__proof strong{color:var(--color-text);font-family:var(--font-mono);font-size:var(--text-sm)}.viewer-intro__proof span{color:var(--color-text-muted);letter-spacing:.07em;text-transform:uppercase;font-size:.65rem;font-weight:700}.viewer[data-viewer-state=loaded] .viewer-intro,.viewer[data-viewer-state=loading] 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